Category: 2002-24-6

Electric Literature of 2002-24-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2002-24-6 as follows.

EXAMPLE 2 N-(3-{4-[3-Chloro-4-(3-fluoro-benzyloxy)-phenylamino]-quinazolin-6-yl}-prop-2-ynyl)-N’-cyano-N”-3-(2-hydroxy-ethyl)guanidine. A mixture of crude 1-(3-{4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-quinazolin-6-yl}-prop-2-ynyl)-2-phenyl-N-cyano-isourea (70 mg, 0.12 mmol) (from Step H, Example 1), 2-hydroxyethylamine hydrochloride (39 mg, 0.4 mmol) and triethylamine (0.07 mL, 0.5 mmol) in isopropanol (2 mL) was heated to 85 C. in a sealed tube. The reaction was cooled to room temperature after 3 hours. Solvent was removed via rotovap. The residue was then purified by FCC to give the final productproduct (25 mg, 38%) as a light yellow solid. MS ESI (+) m/z 544 (M+1) detected; 1H NMR (400 MHz, deuterated DMSO) 9.95 (s, 1H), 8.7 (s, 1H), 8.6 (s, 1H), 8.05 (s,1H), 8.0 (s, 1H), 7.8 (m, 1H), 7.78 (m, 2H), 7.6 (br, 1H), 7.5 (m, 1H), 7.22-7.4 (m, 2H), 7.2 (m, 1H), 7.1 (m, 1H), 5.25 (s, 2H), 4.25 (m, 2H), 3.5 (m, 2H), 3.25 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2002-24-6, its application will become more common.

Reference:
Patent; Wallace, Eli; Topolov, George; Zhao, Qian; Lyssikatos, Joseph P.; US2005/101617; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 2002-24-6, Adding some certain compound to certain chemical reactions, such as: 2002-24-6, name is 2-Aminoethanol hydrochloride,molecular formula is C2H8ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2002-24-6.

1-Nitro-9-Hydroxyethylaminoacridine This compound is synthesised generally using the methods described in EP 38579. Specifically, 2 g of 2-amino-ethanol hydrochloride is added to 6.4 g of 1-nitro-9-phenoxyacridine dissolved in 20 g of freshly distilled phenol. The mixture is heated for 40 minutes at a temperature of 80 C. and then cooled, diluted with ether. It is then poured into dry ether that was acidified with an ethereal solution of hydrogen chloride. The orange colored precipitate of 1-nitro-9-(2-hydroxyethylamino)-acridine hydrochloride, obtained in this way is filtered and crystallized from dry ethanol. The melting point of the compounds obtained was 170 C., with decomposition. Yield 91%. Elementary analysis for the formula: C15H14N3O3Cl:calculated:56.47%; C, 4.42%; H, 13.17%; N. determined: 56.44%; C, 4.40%; H, 13.03%; N.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2002-24-6, 2-Aminoethanol hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Tiwari, Raj; Miller, Daniel G.; Konopa, Jerzy Kazimierz; Wysocka-Skrzela, Barbara; US2002/37831; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2002-24-6, name is 2-Aminoethanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2002-24-6

9-(2′-hydroxyethylamino)-4-methyl-1 -nitroacridine 4-Methyl-1-nitro-9-phenoxyacridine (0.33 g) is dissolved in phenol (10 g), ethanolamine hydrochloride (0.2 g) is added and the mixture is heated at 80 C. for 0.5 hour. The reaction mixture is cooled to room temperature, diluted with ether, slowly poured into dry ether (200 ml) and acidified with ethereal solution of hydrogen chloride. The resulting precipitate is filtered off, washed with ether and crystallized from absolute ethanol to give 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine monohydrochloride as orange crystals (0.27 g, 84%), m.p. 238 C. (decomp.) 1H NMR (d6DMSO): delta2.45 (s, 3H, CH3), 3.48 (q, 2H, H-2′), 3.65 (t, 2H, H-1′), 4.3 (t, 1H, OH), 7.1 (t, 1H, H-7), 2), 7.35 (d, 1H, J=7.8 Hz, H-3), 7.5 (t, 1H, H-6), 7.65 (d, 1H, J=8 Hz, H-5), 7.75 (d,1H, J=8.0 Hz, H-8).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2002-24-6, 2-Aminoethanol hydrochloride.

Reference:
Patent; Konopa, Jerzy Kazimierz; Wysocka-Skrzela, Barbara; Tiwari, Raj; US2002/99211; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 2002-24-6, 2-Aminoethanol hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-Aminoethanol hydrochloride, blongs to alcohols-buliding-blocks compound. Recommanded Product: 2-Aminoethanol hydrochloride

9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine 4-Methyl-1-nitro-9-phenoxyacridine (0.33 g) is dissolved in phenol (10 g), ethanolamine hydrochloride (0.2 g) is added and the mixture is heated at 80 C. for 0.5 hour. The reaction mixture is cooled to room temperature, diluted with ether, slowly poured into dry ether (200 ml) and acidified with ethereal solution of hydrogen chloride. The resulting precipitate is filtered off, washed with ether and crystallized from absolute ethanol to give 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine monohydrochloride as orange crystals (0.27 g, 84%), m.p. 238 C. (decomp.) 1H NMR (d6 DMSO): delta2.45 (s, 3H, CH3), 3.48 (q, 2H, H-2′), 3.65 (t, 2H, H-1′), 4.3 (t, 1H, OH), 7.1 (t, 1H, H-7), 7.24 (d, 1H, J=7.8 Hz, H-2), 7.35 (d, 1H, J=7.8 Hz, H-3), 7.5 (t, 1H, H-6), 7.65 (d, 1H, J=8 Hz, H-5), 7.75 (d,1H, J=8.0 Hz, H-8).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2002-24-6, 2-Aminoethanol hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; New York Medical College; US6589961; (2003); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2002-24-6, name is 2-Aminoethanol hydrochloride, molecular formula is C2H8ClNO, molecular weight is 97.544, as common compound, the synthetic route is as follows.name: 2-Aminoethanol hydrochloride

A dichloromethane (5 ml) solution of the [6-[(4-chlorophenylsulfonyl)(2,5-difluorophenyl)methyl]pyridin-3-yl]carboxylic acid (100 mg, 0.236 mmol) obtained in Example 50 were added triethylamine (80 mul, 0.566 mmol), 4-dimethylaminopyridine (15 mg, 0.118 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (54 mg, 0.283 mmol) and ethanolamine hydrochloride (28 mg, 0.283 mmol). The resulting mixture was stirred at room temperature for 17.5 hours. The reaction mixture was diluted with dichloromethane. The diluted mixture was washed sequentially with water, a saturated aqueous solution of sodium bicarbonate and brine. The organic layer thus obtained was dried over magnesium sulfate and concentrated under reduced pressure. The residue thus obtained was subjected to flash silica gel column chromatography. The fraction obtained from the dichloromethane_methanol=30:1 eluate was concentrated under reduced pressure to give the title compound (69 mg, 0.148 mmol, 63%) as a white powder. 1H-NMR (400MHz, CDCl3) delta: 2.38 (1H,t, J=4.9Hz), 3.65 (2H,td, J=5.4, 4.9Hz), 3.85 (2H,q, J=4.6Hz), 5.99 (1H,s), 6.77 (1H,brs), 6.90-6.96 (1H,m), 7.00-7.06 (1H,m), 7.42 (2H,d, J=8.6Hz), 7.56 (2H,d, J=8.6Hz), 7.70 (1H,d, J=8.1Hz), 7.97-8.01 (1H,m), 8.15 (1H,dd, J=8.1, 2.2Hz), 8.99 (1H,d, J=2.2Hz)H,m), mp: 179 to 181C. Elemental Analysis for C21H17ClF2N2O4S: Calculated: C,54.02; H, 3.67; Cl, 7.59; F,8.14; N,6.00; S,6.87. Found: C, 53.83; H,3.63; Cl, 7.72; F, 8.14; N,6.06; S, 7.02.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2002-24-6, 2-Aminoethanol hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1640366; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 2002-24-6, Adding some certain compound to certain chemical reactions, such as: 2002-24-6, name is 2-Aminoethanol hydrochloride,molecular formula is C2H8ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2002-24-6.

Step A N-tritylethanolamine Ethanolamine hydrochloride (9.9 g; 100 mmol) is partially dissolved in CH2 Cl2 /CH3 CN (200 ml/100 ml) and Et3 N (23 ml; 170 mmol) is then added. Tritylchloride (18.9 g; 67.6 mmol) is added portionwise over 30 minutes. After the addition is complete the reaction mixture is allowed to stir an additional 30 minutes, diluted with CH2 Cl2, washed With H2 O 2* and brine, dried (MgSO4), concentrated in vacuo and purified by column chromatography with silica/CH2 Cl2 to give N-tritylethanolamine as an oil which is used directly in Step B.

According to the analysis of related databases, 2002-24-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Rhone-Poulenc Rorer Pharmaceuticals Inc.; US5455260; (1995); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 2002-24-6, Adding some certain compound to certain chemical reactions, such as: 2002-24-6, name is 2-Aminoethanol hydrochloride,molecular formula is C2H8ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2002-24-6.

Free, i.e., monomeric HMPA was reacted with MEA hydrochloride in the presence of a molecular sieve additive. Conditions of the reaction, conversions and selectivities are shown in Table 12.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2002-24-6, 2-Aminoethanol hydrochloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Monsanto Technology LLC; US2005/54871; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 2002-24-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2002-24-6, name is 2-Aminoethanol hydrochloride, molecular formula is C2H8ClNO, molecular weight is 97.544, as common compound, the synthetic route is as follows.

9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine 4-Methyl-1-nitro-9-phenoxyacridine (0.33 g) is dissolved in phenol (10 g), ethanolamine hydrochloride (0.2 g) is added and the mixture is heated at 80 C. for 0.5 hour. The reaction mixture is cooled to room temperature, diluted with ether, slowly poured into dry ether (200 ml) and acidified with ethereal solution of hydrogen chloride. The resulting precipitate is filtered off, washed with ether and crystallized from absolute ethanol to give 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine monohydrochloride as orange crystals (0.27 g, 84%), m.p. 238 C. (decomp.) 1H NMR (d6DMSO): delta2.45 (s, 3H, CH3), 3.48(q, 2H, H-2′), 3.65 (t, 2H, H-1′), 4.3 (t, 1H, OH), 7.1 (t, 1H, H-7), 7.24 (d, 1H, J=7.8 Hz, H-2), 7.35 (d, 1H, J=7.8 Hz, H-3), 7.5 (t, 1H, H-6), 7.65 (d, 1H, J=8 Hz, H-5), 7.75 (d, 1H, J=8.0 Hz, H-8).

The chemical industry reduces the impact on the environment during synthesis 2002-24-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Tiwari, Raj; Miller, Daniel G.; Konopa, Jerzy Kazimierz; Wysocka-Skrzela, Barbara; US2002/37831; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 2002-24-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2002-24-6, name is 2-Aminoethanol hydrochloride. A new synthetic method of this compound is introduced below.

9-(2′-Hydroxyethylamino)-4-methoxy-1-nitroacridine 4-Methoxy-1-nitro-9-phenoxyacridine (0.346 g) is dissolved in phenol (30 g), ethanolamine hydrochloride (0.12 g) is added and the mixture is heated at 80 C. for 1.5 hour. The reaction mixture is cooled to room temperature, diluted with dry ether (20 ml), slowly poured into dry ether (200 ml) and acidified with ethereal solution of hydrogen chloride. The resulting precipitate is filtered off, washed several times with ether and crystallized from absolute ethanol-ether (5:1) to give 9-(2′-hydroxyethylamino)-4-methoxy-1-nitroacridine monohydrochloride as yellow crystals (0.27 g, 77% yield), m.p. 210-212 C. (decomp.) 1H NMR (for a free base) (d6DMSO): delta10.18 (s, 1 H, NH), 7.78 (d, 1 H, J=7.8 Hz, H-8), 7.67 (d, 1 H, J=8.3 Hz, H-5), 7.47 (t, 1 H, J=7.8 Hz, H-6), 7.36 (d, 1 H, J=8.8 Hz), 7.10 (m, 2 H, H-3, H-7), 4.31 (t, 1 H, J=5.4 Hz, OH), 3.70 (t, 2 H, J=6.4 Hz, H-1′), 3.64 (q, 2 H, J=6.3 Hz, H-2′).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2002-24-6, its application will become more common.

Reference:
Patent; Tiwari, Raj; Miller, Daniel G.; Konopa, Jerzy Kazimierz; Wysocka-Skrzela, Barbara; US2002/37831; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 2002-24-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2002-24-6, name is 2-Aminoethanol hydrochloride. A new synthetic method of this compound is introduced below.

9-(2′-Hydroxyethylamino)-4-methoxy-1-nitroacridine 4-Methoxy-1-nitro-9-phenoxyacridine (0.346 g) is dissolved in phenol (30 g), ethanolamine hydrochloride (0.12 g) is added and the mixture is heated at 80 C. for 1.5 hour. The reaction mixture is cooled to room temperature, diluted with dry ether (20 ml), slowly poured into dry ether (200 ml) and acidified with ethereal solution of hydrogen chloride. The resulting precipitate is filtered off, washed several times with ether and crystallized from absolute ethanol-ether (5:1) to give 9-(2′-hydroxyethylamino)-4-methoxy-1-nitroacridine monohydrochloride as yellow crystals (0.27 g, 77% yield), m.p. 210-212 C. (decomp.) 1H NMR (for a free base) (d6DMSO): delta10.18 (s, 1 H, NH), 7.78 (d, 1 H, J=7.8 Hz, H-8), 7.67 (d, 1 H, J=8.3 Hz, H-5), 7.47 (t, 1 H, J=7.8 Hz, H-6), 7.36 (d, 1 H, J=8.8 Hz), 7.10 (m, 2 H, H-3, H-7), 4.31 (t, 1 H, J=5.4 Hz, OH), 3.70 (t, 2 H, J=6.4 Hz, H-1′), 3.64 (q, 2 H, J=6.3 Hz, H-2′).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2002-24-6, its application will become more common.

Reference:
Patent; Tiwari, Raj; Miller, Daniel G.; Konopa, Jerzy Kazimierz; Wysocka-Skrzela, Barbara; US2002/37831; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts