Reference of 98-55-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.98-55-5, name is 2-(4-Methylcyclohex-3-en-1-yl)propan-2-ol, molecular formula is C10H18O, molecular weight is 154.25, as common compound, the synthetic route is as follows.
A method for preparing 1-p-menthene-8-thiol, comprising the steps of:S1, adding 1 kg of a-terpineol to the reaction vessel, adding 6 L of THF, and stirring until fully dissolved; S2, adding 1.44kg of phosphorus pentasulfide in portions to the solution obtained in step S1, heating up, and controlling temperature below 50 C; S3, reacting at 50 C for 1 hour, monitoring the GC in the gas phase, and the reaction is completed; S4, the reaction system is reduced to room temperature, rotary distillation to remove THF recovery, slowly adding 6L of 10% sodium hydroxide aqueous solution to pH ? 12; S5, extract the aqueous phase twice with a tertiary ether, 3L each time, The organic phase was combined and washed once with saturated brine for 1 L each time. Dry over anhydrous sodium sulfate and concentrate to give 1 kg crude. Distilled under reduced pressure to give 500 g of product 1-p-menthene-8-thiol. GC purity > 85%.
The chemical industry reduces the impact on the environment during synthesis 98-55-5, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Shijiazhuang He Zhong Technology Co., Ltd.; Guo Junyong; Zhang Luanqing; Cao Yanlei; (9 pag.)CN109796385; (2019); A;,
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