Category: 496856-52-1

A general asymmetric synthesis of phenylglycinols was written by Pan, Xingang;Jia, Liangbin;Liu, Xuejian;Ma, Haikuo;Yang, Wenqian;Schwarz, Jacob B.. And the article was included in Tetrahedron: Asymmetry in 2011.SDS of cas: 496856-52-1 The following contents are mentioned in the article:

Hydride reduction and deprotection of siloxymethyl sulfinimines, e.g., I, reliably furnished chiral phenylglycinols, e.g., II or III, in high overall yield and enantiomeric purity. This study involved multiple reactions and reactants, such as (S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol (cas: 496856-52-1SDS of cas: 496856-52-1).

(S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol (cas: 496856-52-1) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.SDS of cas: 496856-52-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors was written by Aronov, Alex M.;Baker, Christopher;Bemis, Guy W.;Cao, Jingrong;Chen, Guanjing;Ford, Pamella J.;Germann, Ursula A.;Green, Jeremy;Hale, Michael R.;Jacobs, Marc;Janetka, James W.;Maltais, Francois;Martinez-Botella, Gabriel;Namchuk, Mark N.;Straub, Judy;Tang, Qing;Xie, Xiaoling. And the article was included in Journal of Medicinal Chemistry in 2007.Name: (S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol The following contents are mentioned in the article:

The Ras/Raf/MEK/ERK signal transduction is a key oncogenic pathway implicated in a variety of human cancers. We have identified a novel series of pyrazolylpyrroles as inhibitors of ERK. Aided by the discovery of two distinct binding modes for the pyrazolylpyrrole scaffold, structure-guided optimization culminated in the discovery of 6p(I), a potent and selective inhibitor of ERK. This study involved multiple reactions and reactants, such as (S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol (cas: 496856-52-1Name: (S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol).

(S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol (cas: 496856-52-1) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: (S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2 was written by Blake, James F.;Gaudino, John J.;De Meese, Jason;Mohr, Peter;Chicarelli, Mark;Tian, Hongqi;Garrey, Rustam;Thomas, Allen;Siedem, Christopher S.;Welch, Michael B.;Kolakowski, Gabrielle;Kaus, Robert;Burkard, Michael;Martinson, Matthew;Chen, Huifen;Dean, Brian;Dudley, Danette A.;Gould, Stephen E.;Pacheco, Patricia;Shahidi-Latham, Sheerin;Wang, Weiru;West, Kristina;Yin, Jianping;Moffat, John;Schwarz, Jacob B.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Synthetic Route of C8H9ClFNO The following contents are mentioned in the article:

The discovery and optimization of a series of tetrahydropyridopyrimidine based extracellular signal-regulated kinase (Erks) inhibitors discovered via HTS and structure based drug design is reported. The compounds demonstrate potent and selective inhibition of Erk2 and knockdown of phospho-RSK levels in HepG2 cells and tumor xenografts. Proliferation of HCT116 (K-RasG12D) and A375 (BRafV600E) cell lines was inhibited by compound (I) with EC50s of 0.74 and 0.39 μM, resp. Pharmacokinetic parameters of I are given. This study involved multiple reactions and reactants, such as (S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol (cas: 496856-52-1Synthetic Route of C8H9ClFNO).

(S)-2-Amino-2-(3-chloro-4-fluorophenyl)ethanol (cas: 496856-52-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C8H9ClFNO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts