Category: 111011-76-8

Adeshra, Shreya D. published the artcileDevelopment and validation of three novel UV spectrophotometric methods for simultaneous estimation of efonidipine hydrochloride ethanolate and telmisartan in their synthetic mixture and its comparison using ANOVA, SDS of cas: 111011-76-8, the publication is Journal of Medicinal and Chemical Sciences (2021), 4(2), 145-153, database is CAplus.

Efonidipine hydrochloride ethanolate and telmisartan combination is used for to treat hypertension treatment and under clin. phase 4 study. It is necessary to develop suitable quality control methods for rapid and accurate determination of these drugs. Three simple, accurate, sensitive, precise and economical UV spectrophotometric methods (A, B and C) have been developed for simultaneous estimation of efonidipine hydrochloride ethanolate and telmisartan in their synthetic mixture Method (A) is based on the first order derivative spectrophotometric method at zero crossing wavelength. In this method the zero crossing zero-crossing point of efonidipine hydrochloride ethanolate is 326 nm and for telmisartan is 272 nm. The linearity was obtained in the concentration range of 8-20 μg/mL for efonidipine hydrochloride ethanolate and 16-40 μg/mL for telmisartan using methanol as a solvent. Method (B) is based on absorbance correction method, method; it was performed at 347 nm for efonidipine hydrochloride ethanolate and at 296 nm for telmisartan. Method (C) is based on dual wavelength method developed using absorbance difference at 242.5 nm and 257.5 nm for efonidipine hydrochloride ethanolate and 244.5 nm and 287 nm for telmisartan. The accuracy and precision of the methods were determined assessed and validated statistically. All the methods showed revealed good reproducibility and recovery. The three methods were compared using one way ANOVA. All methods were found to be rapid, specific, precise and accurate and these methods require no preliminary separation and found no interferences from the tablet excipients so it can be used for routine anal. of both drugs in quality control laboratories

Journal of Medicinal and Chemical Sciences published new progress about 111011-76-8. 111011-76-8 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is 2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate ethanol hydrochloride, and the molecular formula is C36H45ClN3O8P, SDS of cas: 111011-76-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Otsuka, M. published the artcileDevelopmental considerations for ethanolates with regard to stability and physicochemical characterization of efonidipine hydrochloride ethanolate, HPLC of Formula: 111011-76-8, the publication is CrystEngComm (2015), 17(38), 7430-7436, database is CAplus.

Efonidipine hydrochloride ethanolate (NZ-105) is a novel 1,4-dihydropyridine derivative and Ca antagonist. Its chem. structure is distinctive, being a solvate composed of an equimolar adduct of ethanol and efonidipine hydrochloride, and it represents one of a few cases of solvates marketed as a pharmaceutical drug. The research presented in this paper used methods to assess its solid-state properties and included thermal anal. (thermogravimetry-DTA, TG-DTA), Fourier transform IR spectroscopy (FT/IR), evolved gas anal.-mass spectrometry (EGA-MS), environmental (low-vacuum) SEM (E-SEM), variable temperature powder X-ray diffraction, and single-crystal X-ray structure anal., in order to clarify the thermal behavior of the hydrogen chloride and ethanol adducts of efonidipine in the study of the thermal stability of efonidipine hydrochloride ethanolate. Upon heating, efonidipine hydrochloride ethanolate first released ethanol and subsequently formed a decomposition product with the elimination of chloride ions. X-ray diffraction patterns and particulate forms were markedly altered after the release of ethanol, which suggested the interaction of ethanol mols. with chloride ions and efonidipine mols. within the crystal structure. Vastly different from efonidipine, the crystal structure of efonidipine hydrochloride ethanolate arranges the chloride ion within a basket-type conformation formed by the bulky di-Ph and phosphate groups. This distinctive crystal structure was thought to suppress the elimination of chloride ions and contribute significantly to the improved thermal stability of the compound

CrystEngComm published new progress about 111011-76-8. 111011-76-8 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is 2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate ethanol hydrochloride, and the molecular formula is C36H45ClN3O8P, HPLC of Formula: 111011-76-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sakai, Toshinori published the artcileHemodynamic effects of the new dihydropyridine derivative, (±)-2-[benzyl(phenyl)amino]ethyl 1,4-dihydro-2,6-dimethyl-5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-4-(3-nitrophenyl)-3-pyridinecarboxylate hydrochloride ethanol (NZ-105) in anesthetized dogs, SDS of cas: 111011-76-8, the publication is Oyo Yakuri (1991), 42(1), 43-54, database is CAplus.

The hemodynamic effects of NZ-105 (I) were compared with those of nicardipine in pentobarbital-anesthetized dogs. NZ-105 had a slow onset and prolonged duration of action in decreasing blood pressure. Doses of 10-100 μg/kg i.v. produced a dose-dependent fall in blood pressure but no significant increase in heart rate. The potency of NZ-105 on blood pressure was about half that of nicardipine. However, the duration of action of NZ-105 was longer while the extent of the fall was similar. A small dose of 10 μg/kg of NZ-105 i.v. produced a hypotensive effect, but a large dose of 300 μg/kg i.v. was required to cause prolongation of the P-Q interval in the ECG. In open-chest dogs, NZ-105 (10 and 30 μg/kg i.v.) tended to increase the central venous pressure and transiently increased the left ventricular end-diastolic pressure but produced no significant change in the maximal rate of rise of the left ventricular pressure. NZ-105 (10 and 30 μg/kg i.v.) increased the coronary sinus outflow but caused no significant change in myocardial oxygen consumption. These results suggest that NZ-105 may be a useful agent with a slow onset and long duration of action, vascular selectivity and minimal cardiac effect in the treatment of hypertension.

Oyo Yakuri published new progress about 111011-76-8. 111011-76-8 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is 2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate ethanol hydrochloride, and the molecular formula is C36H45ClN3O8P, SDS of cas: 111011-76-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Patel, Grishma H. published the artcileRp-hplc method development and validation for simultaneous estimation of efonidipine hydrochloride ethanolate and telmisartan in their synthetic mixture, Recommanded Product: 2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate ethanol hydrochloride, the publication is International Journal of Pharmaceutics and Drug Analysis (2021), 9(3), 190-195, database is CAplus.

A Novel, selective, accurate and rapid Reversed Phase High Performance Liquid Chromatog. (RPHPLC) method for the anal. of Efonidipine Hydrochloride Ethanolate and Telmisartan in binary mixture has been developed and validated. The chromatog. system consisted of a Phenomenex Kinetex 5μ C18 Size: 150 * 4.6mm column and the separation was achieved by using ambient temperature with a mobile phase containing mobile Phase Acetonitrile:25mM Phosphate Buffer pH 4.9 (45:55). The samples were monitored at 253 nm for detection at a flow rate of 1.0 mL/min and the retention time was about 7.77 and 4.10 mins for Efonidipine Hydrochloride Ehanolate and Telmisartan resp. The calibration curve was linear over the concentration range 5-30 and 10-60μg/mL for Efonidipine Hydrochloride Ehanolate and Telmisartan resp. The proposed method is accurate in the range of 99.75% – 100.10% recovery and precise (%RSD of intraday variation and % RSD of inter day variation were found to be within the acceptance criteria). Therefore, this method can be used as a more convenient and efficient option for the anal. of Efonidipine Hydrochloride Ehanolate and Telmisartan in Quality control laboratory

International Journal of Pharmaceutics and Drug Analysis published new progress about 111011-76-8. 111011-76-8 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is 2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate ethanol hydrochloride, and the molecular formula is C36H45ClN3O8P, Recommanded Product: 2-(Benzyl(phenyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate ethanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts