Category: 69393-72-2

Ye, Hao et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2022 | CAS: 69393-72-2

Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application In Synthesis of Benzo[d][1,3]dioxol-4-ol

Palladium-catalyzed Heck cyclization/carbonylation with formates: synthesis of azaindoline-3-acetates and furoazaindolines was written by Ye, Hao;Wu, Linhui;Zhang, Minrui;Jiang, Guomin;Dai, Hong;Wu, Xin-Xing. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Application In Synthesis of Benzo[d][1,3]dioxol-4-ol This article mentions the following:

Herein a palladium-catalyzed domino cyclization/carbonylation to access ester-functionalized azaindolines, e.g., I applying formates, e.g., phenylformate as a convenient carbonyl source was reported. All four azaindoline isomers were constructed, exhibiting good functional group compatibility. On this basis, modifying the starting tether on the aminopyridine led to furoazaindolines, e.g., II via an intramol. reductive cyclization after the palladium-catalyzed process. In the experiment, the researchers used many compounds, for example, Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2Application In Synthesis of Benzo[d][1,3]dioxol-4-ol).

Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application In Synthesis of Benzo[d][1,3]dioxol-4-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ye, Hao et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2022 | CAS: 69393-72-2

Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application In Synthesis of Benzo[d][1,3]dioxol-4-ol

Palladium-catalyzed Heck cyclization/carbonylation with formates: synthesis of azaindoline-3-acetates and furoazaindolines was written by Ye, Hao;Wu, Linhui;Zhang, Minrui;Jiang, Guomin;Dai, Hong;Wu, Xin-Xing. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Application In Synthesis of Benzo[d][1,3]dioxol-4-ol This article mentions the following:

Herein a palladium-catalyzed domino cyclization/carbonylation to access ester-functionalized azaindolines, e.g., I applying formates, e.g., phenylformate as a convenient carbonyl source was reported. All four azaindoline isomers were constructed, exhibiting good functional group compatibility. On this basis, modifying the starting tether on the aminopyridine led to furoazaindolines, e.g., II via an intramol. reductive cyclization after the palladium-catalyzed process. In the experiment, the researchers used many compounds, for example, Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2Application In Synthesis of Benzo[d][1,3]dioxol-4-ol).

Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application In Synthesis of Benzo[d][1,3]dioxol-4-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Katiyar, Deepti et al. published their research in International Journal of Pharmacy and Pharmaceutical Sciences in 2017 | CAS: 69393-72-2

Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application of 69393-72-2

Isolation, characterization and prediction of biological activity of two new fatty esters and a phenol from the heartwood of Pterocarpus Marsupium Roxb was written by Katiyar, Deepti;Singh, Vijender;Ali, Mohammed. And the article was included in International Journal of Pharmacy and Pharmaceutical Sciences in 2017.Application of 69393-72-2 This article mentions the following:

Objective: The current investigation involves the isolation, characterization and prediction of biol. activity spectra of the phytoconstituents from the ethanolic extract of the heartwood of Pterocarpus marsupium roxb. (Fabaceae). Methods: The heartwood (3 kg) was extracted in alc. by cold maceration for 21 d and the compounds were isolated by column chromatog. The compounds thus isolated were characterised and their structures were elucidated by using assorted spectral data anal., i.e., IR radiation spectroscopy (IR), proton NMR (1HNMR), carbon thirteen NMR (1C3 NMR) and direct anal. in real time mass spectrometry (DART-MS). PASS (prediction of activity spectra for substances) computer program was used to predict the biol. activity spectra of the isolated compounds Results: Phytochem. investigation of ethanolic extract of the heartwood of Pterocarpus marsupium led to isolate two fatty esters and a phenolic compound characterised as n-octanyl n-octadeca-9,12-dienoate (n-octanyl linoleiate, 1), n-dodecanyl n-octadeca-9,12-dienoate (n-dodecanyl linoleiate, 2) and 2, 3-dioxymethylene phenol (3). These phytoconstituents are reported for first time in the heartwood of Pterocarpus marsupium Roxb. The in silico profiling of these phytoconstituents exhibited their broad spectra of biol. activity. Compounds (1) and (2) showed their maximum activity as All-trans-retinyl-palmitate hydrolase inhibitor, anti eczematic, lipid metabolism regulator, etc. and compound (3) was found to be active as membrane integrity agonist, aspulvinone dimethylallyl transferases inhibitor, carminative, neurotransmitter uptake inhibitor, etc. Conclusion: These isolated phytoconstituents can be used as the marker compounds to establish the identity, quality and purity of the drug. The results of PASS prediction shall be very useful for establishing these phytoconstituents as active pharmacol. moieties. In the experiment, the researchers used many compounds, for example, Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2Application of 69393-72-2).

Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application of 69393-72-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Ze-Yu et al. published their research in Chinese Journal of Chemistry in 2014 | CAS: 69393-72-2

Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Category: alcohols-buliding-blocks

Synthesis of chiral α-benzyl-β2-hydroxy carboxylic acids through iridium-catalyzed asymmetric hydrogenation of α-oxymethylcinnamic acids was written by Li, Ze-Yu;Song, Song;Zhu, Shou-Fei;Guo, Na;Wang, Li-Xin;Zhou, Qi-Lin. And the article was included in Chinese Journal of Chemistry in 2014.Category: alcohols-buliding-blocks This article mentions the following:

An asym. hydrogenation of α-oxymethylcinnamic acids was developed by using chiral spiro phosphine-oxazoline/iridium complexes as catalysts to prepare β2-hydroxycarboxylic acids I [R = C6H5, 3,5-(OCH3)2C6H3, C6H4CH2, etc.; Ar = C6H5, 3,4-(OCH2O)C6H3, 3-H3CO-4-C6H5CH2O-C6H3, etc.] with high reactivity (TON up to 2000) and excellent enantioselectivity (up to 99.5% ee) under mild conditions. By using this highly efficient asym. hydrogenation as a key step, a concise enantioselective total synthesis of natural product homoisoflavone II was accomplished in 7 steps with 59% overall yield. In the experiment, the researchers used many compounds, for example, Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2Category: alcohols-buliding-blocks).

Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lin, Shibo et al. published their research in Frontiers in Chemistry (Lausanne, Switzerland) in 2022 | CAS: 69393-72-2

Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application In Synthesis of Benzo[d][1,3]dioxol-4-ol

Palladium-catalyzed allylic etherification of phenols with vinyl ethylene carbonate was written by Lin, Shibo;Zhao, Xiaotian;He, Lihui;Li, Xuanhao;Jiang, Qian;Xiang, Lan;Ye, Yongqin;Gan, Xiaohong. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2022.Application In Synthesis of Benzo[d][1,3]dioxol-4-ol This article mentions the following:

The palladium-catalyzed decarboxylative reactions of phenols and vinyl ethylene carbonate to produce allylic aryl ethers under mild conditions have been established. Adopting an inexpensive PdCl2(dppf) catalyst promotes the efficient conversion of phenols to the corresponding allylic aryl ethers via the formation of a new C-O bond in good isolated yields with complete regioselectivities, acceptable functional group tolerance and operational simplicity. The robust procedure could be completed smoothly by conducting a scaled-up reaction with comparable efficiency to afford the target product. In the experiment, the researchers used many compounds, for example, Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2Application In Synthesis of Benzo[d][1,3]dioxol-4-ol).

Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application In Synthesis of Benzo[d][1,3]dioxol-4-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of Benzo[d][1,3]dioxol-4-ol

The synthetic route of 69393-72-2 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 69393-72-2, Benzo[d][1,3]dioxol-4-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C7H6O3, blongs to alcohols-buliding-blocks compound. COA of Formula: C7H6O3

a) 4-hydroxy-5-(4-propylpiperazinylmethyl)-1,3-benzodioxole Aqueous formaldehyde (37%; 3.67 g, 45.3 mmol) was added dropwise to a stirred solution of 4-hydroxy-1,3-benzodioxole (5.2 g, 37.8 mmol) and N-propylpiperazine (5.8 g, 45.3 mmol) in acetonitrile (25 ml). The reaction mixture was stirred at room temperature for one hour and evaporated in vacuo. The remaining oil (13.0 g) was purified chromatographically (with ethylacetate/methanol=9/1 (v/v) as an eluent to give 4-hydroxy-5-(4-propylpiperazinylmethyl)-1,3-benzodioxole (5.9 g, 56% yield; compound No. 25), m.p. 115-117 C.

The synthetic route of 69393-72-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Duphar International Research B.V.; US5281595; (1994); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Share a compound : 69393-72-2

At the same time, in my other blogs, there are other synthetic methods of this type of compound,69393-72-2, Benzo[d][1,3]dioxol-4-ol, and friends who are interested can also refer to it.

Electric Literature of 69393-72-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 69393-72-2, name is Benzo[d][1,3]dioxol-4-ol. A new synthetic method of this compound is introduced below.

PREPARATION 4 1-Benzyloxy-2,3-Methylenedioxybenzene (Compound of Formula (Va) where R=benzyl and Y=H A solution of 2,3-methylenedioxyphenol (17.45g) and benzyl bromide (27.5 mL) in dimethylformamide (200 ml) was treated with potassium carbonate (35 g), and the mixture was heated at 60 C. overnight. After cooling and filtering, the mixture was evaporated. The residue was dissolved in ethyl acetate and washed with 1 M hydrochloric acid. The organic extract was dried, filtered and evaporated to afford 1-benzyloxy-2,3-methylenedioxybenzene, mp 62-63 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,69393-72-2, Benzo[d][1,3]dioxol-4-ol, and friends who are interested can also refer to it.

Reference:
Patent; Syntex (U.S.A.) Inc.; US4840965; (1989); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts