The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2516-33-8, name is Cyclopropylmethanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks
Typical Procedure 6: To a mixture of 2-cyclopropyl-methanol (6.15 g) and DMF (12 mL) was added NaH (60% in mineral oil, 1.5 g) at 0 C. After stirring for 4 hours at RT, the mixture was diluted with DMF (5 mL) and 5-bromo-2-fluoro-pyridine (6.00 g) was slowly added keeping the reaction temperature below 30 C. After 30 minutes at RT, the mixture was heated to 130 C. for 1 hour by microwave irradiation. After cooling to RT, the mixture was diluted with EA and washed with water (3 times). The organic phase was dried (Na2SO4) and concentrated. The residue was purified by SGC to provide 5-bromo-2-cyclopropylmethoxy-pyridine. MS ESI+: m/z=228 [M+H]+.
With the rapid development of chemical substances, we look forward to future research findings about 2516-33-8.
Reference:
Patent; SANOFI; Schwink, Lothar; Buning, Christian; Glombik, Heiner; Poverlein, Christoph; Ritter, Kurt; Halland, Nis; Lohmann, Matthias; (52 pag.)US2018/237419; (2018); A1;,
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