Reference of 4654-39-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4654-39-1 as follows.
1 -Bromo-4-(2-iodoethyl)benzeneA solution of 2-(4-bromophenyl)ethanol (40.0 g, 0.199 mol) in dichloromethane (10 mL) was added dropwise to a solution of imidazole (22.4 mg, 0.329 mmol), triphenylphosphine (66.5 g, 0.254 mol), and iodine (65.0 g, 0.26 mol) indichloromethane (50 mL) at 0C. When the addition was complete it was warmed to rt. After 1 hour the reaction was filtered through celite, the filtrate was washed with saturated aqueous sodium thiosufate (2×100 mL), brine (100 mL), dried over MgS04, filtered and concentrated in vacuo. Purification by flash column chromatography on silica gel (heptane/ethyl acetate 4: 1 ) afforded the title compound as a yellow-white solid (59.09 g, 60%). 1 HNMR (400 MHz, CHLOROFORM-d) delta ppm 3.14 (t, J=7.69 Hz, 2 H) 3.33 (t, J=7.69 Hz, 2 H) 7.08 (d, J=7.89 Hz, 2 H) 7.45 (d, J=8.31 Hz, 2 H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4654-39-1, its application will become more common.
Reference:
Patent; PFIZER INC.; BROWN, Matthew Frank; MARFAT, Anthony; MELNICK, Michael Joseph; REILLY, Usa; WO2011/45703; (2011); A2;,
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