Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2503-56-2, name is 7-Hydroxy-5-methyl-1,3,4-triazaindolizine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H6N4O
The proper 5- Methyl-[1,2,4] triazolo [1,5-a] Pyrimidin-7-ol (10 mmol) was added to 2.75 ml (30 mmol) of phosphorous oxychloride and heated under reflux for 90 min in a round bottom flask. Excess phosphorous oxychloride was removed by distillation at reduced pressure on a steam bath, and the residue was triturated with ice water. The product was extracted from the aqueous mixture with CH2Cl2, evaporated, and purified by column chromatography using 60% EtOAc/hexane. Yield of the product is 55%. 4.1.4.1. 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine (8). White-yellow solid (Rf = 0.6 in pure ethyl acetate); m.p. 150 C.; 1H NMR (300 MHz, CDCl3): delta 8.50 (s, 1H, Triazolopyrimidine-Hb), 7.15 (s, 1H, Triazolopyrimidine-Ha), 2.75 (s, 3H, Triazolopyrimidine-CH3)LCMS: (ESI, m/z): [M+H]+ calcd for C5H6ClN4 169.1; found: 169.1.
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Reference:
Article; Kumar, Jitendra; Meena, Poonam; Singh, Anju; Jameel, Ehtesham; Maqbool, Mudasir; Mobashir, Mohammad; Shandilya, Ashutosh; Tiwari, Manisha; Hoda, Nasimul; Jayaram; European Journal of Medicinal Chemistry; vol. 119; (2016); p. 260 – 277;,
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