Reference of 112-27-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol. A new synthetic method of this compound is introduced below.
Triethylene glycol (30 g, 0.2 mol) was dissolved in a solution of NaOH (8 g in 8 mL of H2O) and stirred for 10 min. Then benzyl chloride (7 mL, 0.062 mol) was added and the reaction mixture was heated to 100 C. and stirred overnight. The crude reaction was diluted with sat NaCl (500 mL), washed CH2Cl2 (2×400 mL), organic layers dried MgSO4, and evaporated to dryness. Column chromatography (silica, ethyl acetate to ethyl acetate/MeOH, 10:1) afforded 1 a yellowish oil (9.87 g, 67% yield).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,112-27-6, 2,2′-(Ethane-1,2-diylbis(oxy))diethanol, and friends who are interested can also refer to it.
Reference:
Patent; James, Kenneth D.; US2008/207505; (2008); A1;,
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