Adding a certain compound to certain chemical reactions, such as: 637031-88-0, 3,3-Difluorocyclobutanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 637031-88-0, blongs to alcohols-buliding-blocks compound. SDS of cas: 637031-88-0
1-Bromo-4-(3,3-difluorocyclobutoxy)benzene. PPh3 (267 mg, 1.02 mmol) is dissolved in dry toluene (2 mL) and cooled to 0 C. Dropwise, diethyl azodicarboxylate (0.165 mL, 1.02 mmol) is added and the light yellow sol. is stirred at 0 C for 10 min. A sol. of 3,3-difluorocyclobutanol (100 mg, 0.925 mmol) in toluene (0.8 ml) is added. After stirring for another 10 min at rt, 4-bromophenol (160 mg, 0.925 mmol) is added, and the sol. is stirred at 100C overnight. The mixture is allowed to cool to rt, and the solvents are removed under reduced pressure. Purification of the crude by automated FC (Combiflash, 40 g silicagel, EtOAc / heptane 0:100 ? 5:95) yields the title product. LC-MS: tR= 0.94 min (conditions 3).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,637031-88-0, its application will become more common.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BEZENCON, Olivier; GATFIELD, John; HEIDMANN, Bibia; SIEGRIST, Romain; STAMM, Simon; (86 pag.)WO2016/41892; (2016); A1;,
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