The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2077-19-2, name is 2-(4-Bromophenyl)propan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-(4-Bromophenyl)propan-2-ol
To a suspension of 2-(4-bromo-phenyl)-propan-2-ol (1.00 g, 4.65 mmol), copper(l) iodide (177 mg, 0.93 mmol) and sodium (2R)-2-[(2R)-3,4-dihydroxy- 5-oxo-2H-furan-2-yl]-2-hydroxy-ethanolate hydrate (100 mg, 0.46 mmol in amixture of DMF (4 ml) and water (5 ml) are added sodium azide (605 mg, 9.3 mmol) and N,N?-dimethyl-ethane-1,2-diamine (123 mg, 1.39 mmol). The reaction mixture is stirred at room temperature for 19 hours. The reaction mixture is poured into 40 ml saturated aqueous sodium chloride solution. The mixture is extracted with ethyl acetate. The organic phase is dried over sodium sulfate and evaporated. The residue is chromatographed on a silica gel column with cyclohexane/ethyl acetate as eluent to afford 2-(4-azido-phenyl)- propan-2-ol as light brown oil; HPLC/MS 1.47 mm (B), [M-N2-OH] 132. 1H NMR (400 MHz, DMSO-d6) 6 7.49 (d, J = 8.4 Hz, 2H), 7.04 (d, J = 8.4 Hz,2H), 5.01 (s, 1H), 1.41 (s, 6H)
With the rapid development of chemical substances, we look forward to future research findings about 2077-19-2.
Reference:
Patent; MERCK PATENT GMBH; DORSCH, Dieter; MUZERELLE, Mathilde; BURGDORF, Lars; WUCHERER-PLIETKER, Margarita; CZODROWSKI, Paul; ESDAR, Christina; (278 pag.)WO2017/121444; (2017); A1;,
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