Synthetic Route of 78573-45-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, molecular formula is C10H11F3O, molecular weight is 204.19, as common compound, the synthetic route is as follows.
10 kg of dichloromethane was added to a 50 L reactor, and 3-(3-trifluoromethylphenyl)propanol (1 kg, 4.90 mol) and triethylamine (0.59 kg, 5.88 mol) were added in sequence with stirring. The jar was rinsed with 3 kg of dichloromethane. Cool down to -5-10 C, Methanesulfonyl chloride (0.62 kg, 5.39 mol) was slowly added dropwise. The temperature of the reaction system was maintained at -5 to 10 C, and the addition was completed at about 50 to 80 minutes. The incubation was continued until the TLC monitoring reaction was complete and the reaction was completed in about 1 h. 10 kg of water was added under stirring, stirring was continued for 20 min, and the layers were allowed to stand. The organic phase was retained, and the aqueous phase was further extracted with 11 kg of dichloromethane. The organic phase was combined and the aqueous phase was discarded. The organic phase was transferred to a 50 L reactor, cooled to 5-10 C, 10 kg of water was added, stirred for 30 min, allowed to stand for stratification, and the aqueous phase was discarded; the organic phase was washed with 10 kg of 10% NaCl solution, allowed to stand for stratification, and the water phase was discarded. go with. The organic phase was dried over 0.50 kg anhydrous magnesium sulfate and stirred for about 1 h. The magnesium sulfate was filtered off, the reaction kettle was rinsed with 2 kg of dichloromethane and the filter cake was washed, and the organic phases were combined. Transfer the organic phase to the concentrator, Concentrated under reduced pressure to give a yellow oily liquid 1.41kg. HPLC purity: 98.58%.
The chemical industry reduces the impact on the environment during synthesis 78573-45-2, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Jiangsu Yong’an Pharmaceutical Co., Ltd.; Luo Huan; Kang Yanlong; Li Qian; Qiu Chunfang; Liu Kelei; Wang Shuaiwei; (8 pag.)CN109096119; (2018); A;,
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