Adding a certain compound to certain chemical reactions, such as: 67622-86-0, 2-Methyl-1-(methylamino)propan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2-Methyl-1-(methylamino)propan-2-ol, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 2-Methyl-1-(methylamino)propan-2-ol
To a suspension of l-methyl-4-nitro-lH-pyrazole-3-carboxylic acid (639 mg, 3.7 mmol) and 2- methyl-l-(methylamino)propan-2-ol (500 mg, 4.85 mmol) in THF (15 mL) were added HATU (1.57 g, 4.12 mmol) and N-methylmorpholine (2.13 mL, 19.4 mmol) at ambient temperature. The mixture was heated to 70 C and stirred for 16 h. After cooling down to ambient temperature, the reaction mixture was poured into 20 mL HC1 (2N aqueous solution) and extracted with ethyl acetate (2 x 100 mL).The organic layers were washed with water, brine and the solvent was evaporated. The aqueous layer was back-extracted with dichloromethane, dried and concentrated in vacuo. Both residues were combined to give 2.75 g of a semi-solid yellow material. The crude material was purified by silica gel chromatography using a methanol/ethyl acetate gradient to yield the product (1.2 g, 90 %) as colorless oil.MS: M = 257.3 (M+H)+
At the same time, in my other blogs, there are other synthetic methods of this type of compound,67622-86-0, 2-Methyl-1-(methylamino)propan-2-ol, and friends who are interested can also refer to it.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BLEICHER, Konrad; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; GRUBER, Felix; KOERNER, Matthias; KUHN, Bernd; PETERS, Jens-Uwe; RODRIGUEZ SARMIENTO, Rosa Maria; WO2011/154327; (2011); A1;,
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