Application of 3840-31-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3840-31-1 as follows.
The reactants used are 3,4,5-trimethoxybenzyl alcohol (i.e., R1 in formula (I) is 3, 4, 5 and 3Oxy) 1.0 mmol (198.2 mg), the experimental procedure and procedure were the same as in Example 1, aqueous ammonia (1.8 mol / L)The amount of catalyst used in cuprous bromide is5 mol% (7.2 mg), the amount of TEMPO was 5 mol% (7.8 mg), the reaction temperature was 100 C,The reaction time was 20 h and the crude product was purified by column chromatography (petroleum ether: ethyl acetate = 10: 1) to give pure target product with 185.5 mg yield of 96%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3840-31-1, its application will become more common.
Reference:
Patent; Zhejiang University of Technology; Zhang Guofu; Zhao Yiyong; Zhang Guihua; Ding Chengrong; Yu Yidong; Lv Jinghui; (10 pag.)CN106866326; (2017); A;,
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