Reference of 3840-31-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3840-31-1, name is (3,4,5-Trimethoxyphenyl)methanol. A new synthetic method of this compound is introduced below.
General procedure: The compound (3,4,5-trimethoxyphenyl)-methanol 15 (4.5 mmol) was dissolved in THF (15 mL) and added to a stirred suspension of NaH (60%, 5.4 mmol) in THF (5 mL) at 0 C. The reaction mixture was stirred for 30 min at the same temperature. Propargyl bromide (4.9 mmol) was added to the reaction mixture at the same temperature and stirring was continued for an additional 5 h at room temperature. After completion the reaction (TLC), the reaction mixture was quenched with ice water and extract with ethyl acetate (2 * 20 mL). The organic extract was washed with brine, dried over Na2SO4, and solvent removed under reduced pressure. The residue was subjected to silica gel column chromatography purification (ethyl acetate/hexane 1:10) to afford 1,2,3-trimethoxy-5-((prop-2-yn-1-yloxy)methyl)benzene 16.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,3840-31-1, (3,4,5-Trimethoxyphenyl)methanol, and friends who are interested can also refer to it.
Reference:
Article; Suman; Murthy, T. Ramalinga; Rajkumar; Srikanth; Dayakar; Kishor, Chandan; Addlagatta, Anthony; Kalivendi, Shasi V.; Raju, B. China; European Journal of Medicinal Chemistry; vol. 90; (2015); p. 603 – 619;,
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