In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7250-55-7, name is Dimethyl 3-hydroxypentanedioate, the common compound, a new synthetic route is introduced below. Product Details of 7250-55-7
Preparation 29: (l-methyl-5-oxo-pyrtOlidin-3-yl)-acetic acidStep A: 3-methanesulfonyloxy-pentanedioic acid dimethyl esterCommercially available methyl 3-hydroxy-pentanedioic acid dimethyl ester (3.5 g, 20 mmol) was dissolved in DCM (50 mL) and Et3N (5.6 mL, 40 mmol) was added thereto. The reaction solution was cooled to 0C, and MsCl (2.75 g, 24 mmol) was added dropwise thereto, followed by stirring at room temperature for 2 hours. After the reaction was complete, NH4Cl was added to the reaction solution, followed by extraction with EtOAc. The organic extract was dried over MgSO4 and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: EtOAc: n-Hex = 1/5) to afford the title compound (4.77 g, 94%).MS[M+1] = 241 (M+l)
The synthetic route of 7250-55-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LG LIFE SCIENCES, LTD.; WO2009/38412; (2009); A2;,
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