Adding a certain compound to certain chemical reactions, such as: 229027-89-8, 2-Bromo-4-fluorobenzyl Alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 229027-89-8, blongs to alcohols-buliding-blocks compound. Recommanded Product: 229027-89-8
General procedure: To a solution of compound 7 in DCM was added compound 8 (0.12mmol) and K2CO3 (0.24mmol) The resulting mixture was refluxed at 80C for 3h before it was quenched with 5mL of brine The organic layer was collected and purified by flash column chromatography on a silica column using cyclohexane/acetone (0-50%) to get compound 9.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,229027-89-8, 2-Bromo-4-fluorobenzyl Alcohol, and friends who are interested can also refer to it.
Reference:
Article; Pan, Ting; Ding, Yanchao; Wu, Liyang; Liang, Liting; He, Xin; Li, Qianwen; Bai, Chuan; Zhang, Hui; European Journal of Medicinal Chemistry; vol. 166; (2019); p. 480 – 501;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts