Adding a certain compound to certain chemical reactions, such as: 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, blongs to alcohols-buliding-blocks compound. Safety of 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol
A 500 mL three-necked flask equipped with a water trap was charged with 1-hydroxypyrene (Ea0,623 mg, 2.85 mmol), a propargyl alcohol derivative (E0, 903 mg, 3.36 mmol)3.5g of acidic alumina and 300mL of toluene, under argon protection, dark reaction 90 C for 35h, the solution was dark green.After cooling to room temperature, the reaction mixture was suction filtered, the filter cake was washed with dichloromethane, the filtrate and the washings were combined, the solvent was spin dried,The crude product was separated by column chromatography, and the resulting crude product was recrystallized from absolute ethanol to give 210 mg of a light yellow solid in a yield of 22%. Yield 55%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, and friends who are interested can also refer to it.
Reference:
Patent; Shanghai Gantian Optical Materials Co., Ltd.; Gan Jiaan; (9 pag.)CN104016996; (2017); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts