The origin of a common compound about (2-Amino-4-methylphenyl)methanol

At the same time, in my other blogs, there are other synthetic methods of this type of compound,81335-87-7, (2-Amino-4-methylphenyl)methanol, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.81335-87-7, name is (2-Amino-4-methylphenyl)methanol, molecular formula is C8H11NO, molecular weight is 137.18, as common compound, the synthetic route is as follows.Safety of (2-Amino-4-methylphenyl)methanol

To a solution of (2-amino-4-methylphenyl)-methanol (3.2 g, 23.4 mmol) in THF (40 mL) is added di-ferf-butyl dicarbonate (6.54 g, 28.0 mmol) and the solution is stirred at 60 0C for 5 h. The solvent is evaporated, and water is added. It is then extracted with EtOAc, washed with water, dried with MgSO4 and concentrated. The residue is purified to give the title compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,81335-87-7, (2-Amino-4-methylphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GmbH; WO2007/67612; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts