Synthetic Route of 13588-28-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13588-28-8, name is 2-(2-Methoxypropoxy)propan-1-ol, molecular formula is C7H16O3, molecular weight is 148.2001, as common compound, the synthetic route is as follows.
In a 500 mL flask, flake-like sodium hydroxide (manufactured by Tosoh Corporation) (hereinafter also referred to as”NaOH tablets”) 51.5 g (relative to the following DPMI moles,Equivalent to 1. 4 moles)And 1-bromopropane (manufactured by Wako Pure Chemical Industries, Ltd.) (hereinafter also referred to as “PrBr”) 144.2 g(Relative to the following DPMI moles,Equivalent to 1. 3 moles)Start stirring.After raising the liquid temperature to 35 C,While keeping the temperature inside the system at 35 C,(Hereinafter referred to as “DPM”) was added dropwise over 6 hours to a solution of 133.7 g of dipropylene glycol monomethyl ether (isomer mixture) (manufactured by Wako Pure Chemical Industries, Ltd.).Thereafter,The overnight stirring was carried out while maintaining the temperature of 35 C.In addition,The amount of propylene gas as a low boiling compound produced in the above reaction was measured using a gas flow meter.The reaction solution was added with water 118. After 5 g, extraction /The resulting organic phase 194. 6 g was analyzed by gas chromatography,As a result, it was found that dipropylene glycol methyl n-propyl ether (isomer mixture) (hereinafter also referred to as “DPMNP”) 136.3 g (DPM basis yield: 79.4%, PrBr basis yield: 61 . 1% ).
Statistics shows that 13588-28-8 is playing an increasingly important role. we look forward to future research findings about 2-(2-Methoxypropoxy)propan-1-ol.
Reference:
Patent; Daicel Corporation; Mori, Atsushi; (9 pag.)CN105503545; (2016); A;,
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