Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 813-99-0, name is 3-Chloro-2,2-bis(chloromethyl)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks
3-Chloro-2,2-bis (chloromethyl) propan-1-ol (15.4 g, 80.4 mmol) obtained in the above step 1 was dissolved in 98% ethanol (28 ml) and potassium hydroxide (5.0 g, mmol) was added, and the mixture was heated and refluxed for 30 minutes.The reaction solution was cooled with ice water and stirred for 10 minutes. The resulting solid was filtered off,The pH was adjusted to 7.5 with 2N aqueous hydrochloric acid solution. After removing the solvent by distillation under reduced pressure, water (100 ml) was added to the residue and extracted twice with ethyl acetate (150 ml). The obtained organic layers were combined, washed with brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure.The obtained residue was purified by silica gel column chromatography (hexane: ethyl acetate = 4: 1) to obtain pure 3,3-bis (chloromethyl) oxetane (9.2 g, 74%).
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Reference:
Patent; Korea Research Institute of Chemical Technology; Eseuti Pam Co., Ltd.; Kim Bong-jin; Kim Jae-hak; Lee Il-yeong; Lee Sang-ho; Lee Jong-gyo; Kim Gyeong-jin; Kim Uk-il; Nam Hwa-jeong; (56 pag.)KR101592370; (2016); B1;,
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