Synthetic Route of 81335-87-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 81335-87-7, name is (2-Amino-4-methylphenyl)methanol. A new synthetic method of this compound is introduced below.
Sub-1 (35.0g, 255.1mmol), 3′-methylacetophenone (51.4g, 382.7mmol), tris (triphenylphosphine) ruthenium (II) dichloride (2mol%) and Potassium hydroxide (15.7g, 280.7mmol) and toluene (300mL) were added to the reaction flask, heated and stirred to reflux, and water was separated by a reflux reflux condenser. When the reaction is over, drop to room temperature and filter on a pad of silica gel. The product was further purified by column (eluent: n-hexane / ethyl acetate = 2/100), and finally the intermediate Sub-2 (35.1 g, yield 59%) was obtained by crystallization from isopropanol.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,81335-87-7, its application will become more common.
Reference:
Patent; Zhejiang Huaxian Optoelectric Technology Co., Ltd.; Zheng Xianzhe; Zhao Xiaoyu; Hua Wanming; (31 pag.)CN110452271; (2019); A;,
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