Adding a certain compound to certain chemical reactions, such as: 144284-25-3, 2,4,5-Trifluorobenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 144284-25-3, blongs to alcohols-buliding-blocks compound. Computed Properties of C7H5F3O
General procedure: Triphenylphosphonium salts 49 and 50 were obtained by treating alcohols 47 and 48 (4.5 mmol) in MeCN/THF (1:1, 10 mL) with Ph3P.HBr (3.12 g, 9 mmol). The resulting reaction mixture was heated at 80 C to complete the reaction (as indicated by TLC). The solvents were evaporated and the oily residues were triturated with Et2O. After overnight refrigeration and filtration of the precipitates, the corresponding salts were obtained and used without further purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,144284-25-3, its application will become more common.
Reference:
Article; Magoulas, George E.; Bariamis, Stavros E.; Athanassopoulos, Constantinos M.; Haskopoulos, Anastasios; Dedes, Petros G.; Krokidis, Marios G.; Karamanos, Nikos K.; Kletsas, Dimitris; Papaioannou, Dionissios; Maroulis, George; European Journal of Medicinal Chemistry; vol. 46; 2; (2011); p. 721 – 737;,
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