In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52059-53-7, name is 2-(3-Fluorophenyl)ethanol, the common compound, a new synthetic route is introduced below. HPLC of Formula: C8H9FO
General procedure: To a neat mixture of 3-(3-((6-fluoropyridin-3-yl)methyl)isoxazol-5-yl)pyridin-2-amine (Intermediate IV, 50 mg, 0.19 mmol) and (3-fluorophenyl)methanol (187 mg, 1.48 mmol) was added potassium tert-butoxide (1M in THF, 1.85 mL, 1.85 mmol) and the mixture was stirred for 30 min. The mixture was transferred to a silica gel samplet and purified by column chromatography (SiO2, hexane/ethyl acetate). Combined fractions containing the product were concentrated under reduced pressure. Residue was dissolved in acetonitrile (5 mL) and water (10 mL), frozen and lyophilized to yield 3-(3-((6-((3-fluorobenzyl)oxy)pyridin-3-yl)methyl)isoxazol-5-yl)pyridin-2-amine (45 mg, 0.12 mmol, 65%) as a white solid.
The synthetic route of 52059-53-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Trzoss, Michael; Covel, Jonathan A.; Kapoor, Mili; Moloney, Molly K.; Soltow, Quinlyn A.; Webb, Peter J.; Shaw, Karen Joy; Bioorganic and Medicinal Chemistry Letters; vol. 29; 23; (2019);,
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