Adding a certain compound to certain chemical reactions, such as: 2566-44-1, 2-Cyclopropylethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2566-44-1, blongs to alcohols-buliding-blocks compound. SDS of cas: 2566-44-1
Reference Example 11-1 4-(2-Cyclopropylethoxy)benzaldehyde To a mixture of 4-hydroxybenzaldehyde (2.84 g), 2-cyclopropylethanol (2.00 g), triphenylphosphine (6.09 g) and tetrahydrofuran (100 mL), diethyl azodicarboxylate (2.2 mol/L, solution in toluene, 10.5 mL) was added and the mixture was stirred at room temperature for 4 days. After concentrating the reaction mixture under reduced pressure, ethyl acetate (7.50 mL) and n-hexane (143 mL) were added and the mixture was stirred at room temperature for 15 minutes. The precipitate was removed by filtration through Celite (registered trademark). The filtrate was concentrated under reduced pressure and, thereafter, the resulting residue was purified by silica gel column chromatography (n-hexane:ethyl acetate = 95:5-50:50) to give the titled compound as a yellow oil (3.34 g). 1H NMR (300 MHz, CHLOROFORM-d) delta ppm 0.10 – 0.18 (m, 2 H) 0.46 – 0.55 (m, 2 H) 0.78 – 0.95 (m, 1 H) 1.67 – 1.76 (m, 2 H) 4.12 (t, J=6.6 Hz, 2 H) 6.97 – 7.05 (m, 2 H) 7.80-7.87 (m, 2 H) 9.88 (s, 1 H). MS ESI posi: 191[M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2566-44-1, its application will become more common.
Reference:
Patent; Taisho Pharmaceutical Co., Ltd.; TAKAYAMA, Tetsuo; SHIBATA, Tsuyoshi; SHIOZAWA, Fumiyasu; KAWABE, Kenichi; SHIMIZU, Yuki; HAMADA, Makoto; HIRATATE, Akira; TAKAHASHI, Masato; USHIYAMA, Fumihito; OI, Takahiro; SHIRASAKI, Yoshihisa; MATSUDA, Daisuke; KOIZUMI, Chie; KATO, Sota; EP2881384; (2015); A1;,
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