Synthetic Route of 14002-80-3, Adding some certain compound to certain chemical reactions, such as: 14002-80-3, name is Methyl 3-hydroxy-2,2-dimethylpropanoate,molecular formula is C6H12O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14002-80-3.
[0417] Synthesis of methyl 2,2-dimethyl-3-oxopropanoate (91A): To a suspension of methyl 2,2-dimethyl-3-hydroxypropionate (1.93 ml, 15.1 mmol) and trichloroisocyanuric acid (3.52 g, 15.1 mmol) in dichloromethane (30 ml) was added TEMPO (50 mg, 0.3 mmol) at 0 C. The reaction was warmed to room temperature and stirred for 3 hours. The mixture was filtered and the filtrate was washed with 1M sodium bicarbonate (30mL), followed by 1M HC1 (30 mL), and brine (30 mL). The organic layer was dried with sodium sulfate, filtered, and concentrated under vacuum. The crude product was taken to the next step without further purification.
According to the analysis of related databases, 14002-80-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GILEAD SCIENCES, INC.; BRIZGYS, Gediminas; CANALES, Eda; HALCOMB, Randall, L.; HU, Yunfeng, Eric; KATO, Darryl; LINK, John, O.; LIU, Qi; SAITO, Roland, D.; TSE, Winston, C.; ZHANG, Jennifer, R.; (253 pag.)WO2016/33243; (2016); A1;,
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