Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 23783-42-8, name is 2,5,8,11-Tetraoxatridecan-13-ol. This compound has unique chemical properties. The synthetic route is as follows. name: 2,5,8,11-Tetraoxatridecan-13-ol
Tetraethyleneglycol monomethyl ether (1 .91 ml, 9 mmol) dissolved in dry and degassed DMF (3.5 ml, dried 24 h, 4A MS) was added carefully to sodium hydride (365 mg, 9 mmol) in dry and degassed DMF (15 ml, dried 24 h, 4A MS) under nitrogen at 0 C using a syringe. The temperature was then raised to room temperature and the reaction mixture was stirred for another 30 min. 3-(3-bromo-2,2-bis(bromomethyl)propoxy)prop-1 -ene (730 mg, 2.0 mmol) was then added and the temperature was raised to 100 C. After 14 h the reaction was completed (HPLC-ELSD-C18, 95:5 to 5:95 H2O/ACN in 25 min, Rt product = 19.5 min) the temperature was decreased to room temperature and the reaction mixture was carefully added to H2O (150 ml) and the H2O-phase was washed with diethyl ether (2 x 50 ml). Sodium chloride was then added to the H2O-phase until saturation. The H2O-phase was extracted with EtOAc (4 x 50 ml) and the combined organic phases were washed with brine (2 x 30 ml). Sodium sulfate and charcoal was added to the organic phase. The clear organic phase was filtered and the volatile material was removed at reduced pressure (8 mm Hg, 40 C then 0.1 mm Hg (oil pump) and 40 C to remove residual DMF). Column chromatography (EtOAc:MeOH 9:1 ) gave 1 .05 g (70%) of the product. 1H-NMR (CDCI3); 5.90 (m, 1 H), 5.20 (m, 2H), 3.94 (dt, 2H), 3.70-3.55 (m, 48H), 3.45 (s, 6H), 3.43 (s, 2H), 3.40 (s, 9H).
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Reference:
Patent; SPAGO IMAGING AB; AXELSSON, Oskar; PETORAL JR., Rodrigo M.; EK, Fredrik; LAURITZSON, Petter; WO2013/41623; (2013); A1;,
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