Adding a certain compound to certain chemical reactions, such as: 4728-12-5, (2,2-Dimethyl-1,3-dioxan-5-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C7H14O3, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C7H14O3
A solution of (2,2-dimethyl-1 ,3-dioxan-5-yl)methanol (2.51 g, 17.1 mmol) and N, N- dimethylaminopyiridine (208 mg, 1.7 mmol) in dichloromethane (100 ml.) was cooled to 0 0C and p-toluenesulfonyl chloride (3.59 g, 18.8 mmol) and triethylamine (4.8 ml. 34.2 mmol) were added. The mixture was stirred overnight at rt, diluted with water, and the organic layer was separated. The solvent was removed and the crude material was purified via silica gel chromatography to give 4.16 g of the title compound. 1H NMR (DMSOd6) delta 7.78 (d, 2 H), 7.47 (d, 2 H), 4.09 (d, 2 H), 3.84 (dd, 2 H), 3.52 (dd, 2 H), 2.41 (s, 3 H), 1.79 – 1.94 (m, 1 H), 1.28 (s, 3 H), 1.18 (s, 3 H).
The synthetic route of 4728-12-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/157330; (2008); A1;,
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