Synthetic Route of 431-38-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.
A suspension of intermediate Int-21 (1.0 equiv.) and (0487) racemic-3- Amino- l,l,l-trifluoro-propan-2-ol (3.0 equiv.), and triethylamine (5.0 equiv) in 3: 1 dioxane/water (1.3 mL) was heated at 90 C for 12 hours, after which LC-MS analysis indicated that the conversion was complete. The reaction mixture was diluted with water and adjusted to pH 6-7 with 1.0 N aqueous hydrochloric acid solution, leading to the formation of an orange precipitate. The solid was filtered and dried. Purification of the crude solid was achieved by reverse phase HPLC utilizing a gradient of 10 to 40 % acetonitrile in water (modified by 0.1% trifluoroacetic acid) over 20min to afford racemic Compound 1-11 (57.4 mg, 48 % yield) as an off-white solid. 1H NMR: (500 MHz, CD3OD), d (ppm): 9.63 (s, 1 H), 8.61 (s, 1 H), 7.74 (s, 1 H), 7.30 – 7.33 (m, 1 H), 7.15 – 7.20 (m, 1 H), 6.97 – 7.01 (m, 2 H, overlapping shifts), 4.67 (s, 2 H), 4.28 – 4.32 (m, 1 H), 3.98 – 4.02 (m, 4 H, overlapping shifts), 3.86 – 3.91 (m, 1 H). MS ES+ m/z 464.2 [M+H]+
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol.
Reference:
Patent; CYCLERION THERAPEUTICS, INC.; RENNIE, Glen, Robert; RENHOWE, Paul, Allan; NAKAI, Takashi; MERMERIAN, Ara; CUMBERBATCH, Helen; (99 pag.)WO2019/126354; (2019); A1;,
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