Adding a certain compound to certain chemical reactions, such as: 75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 75476-86-7, blongs to alcohols-buliding-blocks compound. SDS of cas: 75476-86-7
A solution of 6-bromo-indan-1-ol (1 mmol) and NEt3 (4 mmol) in dry THF (5 mL) was stirred at -15 C under argon. A solution of methanesulfonyl chloride (2 mmol) in dry THF (1 mL) was cooled to -78 C and then slowly added to the alcohol solution maintaining the temperature below 0 C. The reaction mixture was stirred for 2h at -15 C and then purged with dimethylamine gas (12 mmol). The reaction mixture was allowed to warm to room temperature and stirred overnight. Then, it was filtered to remove salts and solvent was evaporated. Crude was dissolved in CH2Cl2 and extracted with HCl 1 M (3x). The aqueous phase was basified with NaOH 6M to pH 8-9 and extracted with CH2Cl2. The combined organic extracts were dried over MgSO4 and concentrated to dryness. The crude was used in next step without further purification.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, and friends who are interested can also refer to it.
Reference:
Patent; Laboratorios del. Dr. Esteve, S.A.; EP2308849; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts