Electric Literature of 931-17-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.931-17-9, name is 1,2-Cyclohexanediol, molecular formula is C6H12O2, molecular weight is 116.16, as common compound, the synthetic route is as follows.
Cyclohexanediol 10g, dichloromethane 20 ml,. The oxidizing system after grinding (sodium periodate 20g: silicon dioxide 16g=1: 0.8, 50 microns) was added into the reactor. Constant temperature 40 C, stirring 600r/min, so that sodium periodate is highly dispersed in the anhydrous reaction system. Reflux dichloromethane reaction 2h.Wherein the oxidizing agent prepared according to the following method: 20g sodium periodate was added to 200g 40-70 C water. Under stirring condition is completely dissolved, then pour into 16g silica gel. After intense mechanical stirring 30 minutes, the moisture is removed by evaporation, the residual moisture in the control solid 3% the following, until the high sodium iodate/silica gel into solid-state of fluid.After the reaction solution filtration and separation with oxygen-containing activator system of the solid. Filtrate under reduced pressure after the distillation gas chromatographic – mass spectrometer detection found, hexanedial purity 99.8%, hexanedial quality 8.96g, 1,2-cyclohexanediol conversion 99%, yield is 91.2%.
The chemical industry reduces the impact on the environment during synthesis 931-17-9, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Beijing Xuyang Technology Co., Ltd.; Zhang Yingwei; Su Sizheng; Zhang Minsheng; Cao Yalin; Cui Bingbing; (9 pag.)CN104262168; (2017); B;,
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