Reference of 5259-98-3 , The common heterocyclic compound, 5259-98-3, name is 5-Chloropentan-1-ol, molecular formula is C5H11ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Synthesis of Compound 13 To a solution of 5-chloro-l-pentanol (3.0 g, 24.47 mmol) Compound 11 in DMF (20 mL) was added sodium azide (1.909 g, 29.4 mmol) Compound 12. After being stirred at 60 ¡ãC for overnight, the reaction mixture was concentrated in vacu. The residue was purified by silica gel chromatography (EtOAc/Hexane 1 :3), to give product Compound 13 as clear liquid. 1H NMR (500 MHz, CDC13) delta 3.62 (m, 2H), 3.25 (t, J= 6.9 Hz, 2H), 1.63-1.53 (m, 4H), 1.45-1.40 (m, 2H).
The synthetic route of 5259-98-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; TELLERS, David; COLLETTI, Steven, L.; DUDKIN, Vadim; AARONSON, Jeffrey; MOMOSE, Aaron; TUCKER, Thomas, Joseph; YUAN, Yu; CALATI, Kathleen, B.; TIAN, Lu; PARMAR, Rubina, G.; SHAW, Anthony, W.; WANG, Weimin; STORR, Rachel, Anne; BUSUEK, Marina; KOWTONIUK, Robert, A.; WO2013/166155; (2013); A1;,
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