Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6282-88-8, name is 3-(4-Chlorophenyl)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. name: 3-(4-Chlorophenyl)propan-1-ol
3- (4-chlorophenyl) propanol (17.1g, 0.1mol) was added to DMF (150ml) added successively N- (3- chloropropyl) piperidine (17.8g, 0.11mol), potassium carbonate (6.9g, 0.05mol), potassium iodide 1g, was heated to 95 , the reaction was stirred for 12 hours.The mixture was cooled to room temperature, then diluted with 300ml water, extracted twice with 400ml of ethyl acetate, the combined organic phases, 2N sodium hydroxide and twice with brine, dried over magnesium sulfate, filtered, and HCl at room temperature gas, stirring the precipitated solid was filtered and dried to give light yellow solid solution of 29.8 g, yield 89.7%, HPLC: 99.6%.
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Reference:
Patent; Reyoung Pharmaceutical Co.,Ltd; Hu, qingwen; Cai, lianhui; Cao, Yan; Yu, zhibo; (7 pag.)CN104447620; (2016); B;,
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