Reference of 2568-33-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2568-33-4, name is 3-Methylbutane-1,3-diol, molecular formula is C5H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Into a 1 L three-necked flask equipped with a stirrer, a dry air inlet tube, a thermometer, a distillation column (inner diameter 25 mm ¡Á height 300 mm, packing tower packed with 6 mm McMahon packing) and a distillation head,100 g of 3-methyl-3-hydroxy-1-butyl alcohol, 240 g of methyl methacrylate,0.24 g of 2,2,6,6-tetramethyl-4-hydroxypiperidine-N-oxide as a polymerization inhibitor was charged,While stirring while blowing a small amount of air,The inside of the system was heated to 100 to 110 C. 8 g of methyl methacrylate was withdrawn from the top portion of the distillation column. After cooling the inside of the system to 40 C., 0.55 g of magnesium diethoxide was charged as a catalyst, and a small amountWhile blowing air while stirring,The inside of the system was heated to 100 to 130 C. Methanol produced as the reaction proceeded was gradually withdrawn from the top of the distillation column by azeotropic distillation with methyl methacrylate to allow the reaction to proceed.The conversion of 3-methyl-3-hydroxy-1-butyl alcohol 7 hours after the start of the reaction was 78.3%. The reaction was further continued, and after 9 hours from the start of the reactionThe conversion of 3-methyl-3-hydroxy-1-butyl alcohol was 94.0%The yield of 3-methyl-3-hydroxy-1-butyl methacrylate based on 3-methyl-3-hydroxy-89.3%,The diester yield based on 3-methyl-3-hydroxy-1-butyl alcohol was 1.7%.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2568-33-4, 3-Methylbutane-1,3-diol.
Reference:
Patent; Mitsubishi Gas Chemical Company; Kushida, Eriko; Takemoto, Makiko; (16 pag.)JP2018/135285; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts