Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 15484-46-5, name is Methyl 2-(hydroxymethyl)acrylate. A new synthetic method of this compound is introduced below., Recommanded Product: 15484-46-5
General procedure: Into a round bottom flask charged with a magnetic stirbar was added 1 equiv. MBH adduct, followed by 3 equiv. 33wt % HBr (in HOAc). The solution was vigorously stirred until judged complete by TLC, then was poured into a 1 : 1 (volumetric) mixture of deionized water and CH2Cl2. The organic layer was separated, then the residual product was extracted from the aqueous layer with an additional portion of CH2Cl2. The combined organic layers were washed with deionized water then brine, then were dried with Na2SO4, filtered, concentrated, and purified via column chromatography.
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Reference:
Article; Nicponski, Daniel R.; Tetrahedron Letters; vol. 55; 13; (2014); p. 2075 – 2077;,
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