According to the analysis of related databases, 552331-15-4, the application of this compound in the production field has become more and more popular.
Reference of 552331-15-4, Adding some certain compound to certain chemical reactions, such as: 552331-15-4, name is 1-(5-Bromo-2-fluorophenyl)ethanol,molecular formula is C8H8BrFO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 552331-15-4.
Preparation of 5-bromo-3-methyl-1/-/-indazole 104; Scheme 2 EPO To a solution of 5-bromo-2-fluorobenzaldehydbeta 101 (100 g, 0.492 mol.) in ether (500 ml_), cooled in an ice bath, was added a 3 M solution of methyl magnesium bromide in ether (i.e., diethyl ether) (173 mL, 0.516 mol.) in a dropwise manner. The reaction mixture was stirred for 30 minutes in the ice bath. The reaction mixture was allowed to warm to room temperature and was stirred for 15 minutes. The reaction mixture was cooled in an ice bath and the reaction was quenched by addition of water in a dropwise manner. The reaction mixture was acidified with dilute hydrochloric acid. The organic layer was separated. The aqueous layer was extracted with ether for two times. The combined organic layer was dried over magnesium sulfate and evaporated under reduced pressure to afford 1-(5-bromo-2-fluoro-phenyl)- ethanol 102 (106 g, 0.484 mol.) which was used in the next step without further purification. To a solution of 1 -(5-bromo-2-f luoro-phenyl)-ethanol 102 (105 g, 0.479 mol.) in dioxane (2 L) was added manganese dioxide (203 g, 2.35 mol.). The reaction mixture was heated under reflux for 5 hours. The reaction mixture was allowed to cool to room temperature. The reaction mixture was filtered through Celite (i.e., diatomaceous earth) and the solid was washed with ether (1 L). The combined filtrate was evaporated under reduced pressure to afford the 1-(5-bromo-2-fluoro-phenyl)-ethanone 103 (95.7 g, 0.441 mol.) which was used in the next step without further purification.
According to the analysis of related databases, 552331-15-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SCHERING CORPORATION; WO2006/81230; (2006); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts