Synthetic Route of 6971-51-3 , The common heterocyclic compound, 6971-51-3, name is (3-Methoxyphenyl)methanol, molecular formula is C8H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step (1) Preparation of 3-Methoxybenzyl Bromide To cooled (15 to 20 C.) hydrobromic acid (3.22 kg) (48%) is added 3-methoxybenzyl alcohol (1 kg) dropwise over a period of 1 hour. A slight exotherm results with pot temperature rising from 20 to 23 C. After the addition, the reaction mixture was stirred at 23 to 27 C. for four days. The product separated as an oil during this period. The reaction mixture was transferred to a separatory funnel, and the lower layer containing the product was separated. The aqueous phase was extracted with methylene chloride (750 mL). The methylene chloride extract was combined with the main product and washed with water (500 mL*3). The pH of the last wash was 6.5 to 7.0. The product was dried over anhydrous sodium sulfate (200 g), filtered and concentrated under reduced pressure (bath temperature 50 to 55 C.) to remove most of the solvent, then further concentrated at 40 to 45 C. under 5 mm Hg to constant weight to yield 1.30 kg (89% yield) of crude product. The presence of 5.5% of starting material in this product does not interfere with the subsequent alkylation reaction.
The synthetic route of 6971-51-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; American Home Products Corporation; US5001238; (1991); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts