Related Products of 623-04-1, Adding some certain compound to certain chemical reactions, such as: 623-04-1, name is (4-Aminophenyl)methanol,molecular formula is C7H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 623-04-1.
(4-Aminophenyl)methannol 6a (2.00 g, 16 mmol) was dissolved in 6MHCl (16 mL). Sodium nitrate (1.67 g, 24 mmol) was added slowly at 0 C. After stirring at sametemperature for 30 min, sodium azide (4.23 g, 65 mmol) was added slowly at 0 C. The reaction mixturewas stirred at same temperature for 30 min then extracted with Et2O twice. The organic layer was washedwith saturated aq. NaHCO3 and saturated aq. NaCl, dried over MgSO4, filtrated and concentrated. Theresidue was subjected to silica column chromatography (AcOEt : hexane = 1 : 1) to afford yellow oil(2.17 g, 90%). IR (neat, cm-1) 2154. 1H-NMR (CDCl3) delta: 7.24 (2H, d, J = 8.6 Hz), 6.94 (2H, d, J = 8.6Hz), 4.52 (2H, s), 3.27 (1H, s). 13C-NMR (CDCl3) delta: 139.0, 137.4, 128.3, 118.8, 64.1. ESI-TOF-MS:[M+H]+ calculated for C7H7N3O 150.0667, found 150.0663.
According to the analysis of related databases, 623-04-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Hashimoto, Makoto; Yoshida, Takuma; Tachrim, Zetryana Puteri; Sakihama, Yasuko; Hashidoko, Yasuyuki; Hatanaka, Yasumaru; Kanaoka, Yuichi; Heterocycles; vol. 95; 1; (2017); p. 462 – 473;,
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