《Reversible and Tunable Photoswitching of Protein Function through Genetic Encoding of Azobenzene Amino Acids in Mammalian Cells》 was published in ChemBioChem in 2018. These research results belong to Luo, Ji; Samanta, Subhas; Convertino, Marino; Dokholyan, Nikolay V.; Deiters, Alexander. SDS of cas: 1123172-89-3 The article mentions the following:
The genetic encoding of three different azobenzene phenylalanines with different photochem. properties was achieved in human cells by using an engineered pyrrolysyl tRNA/tRNA synthetase pair. In order to demonstrate reversible light control of protein function, azobenzenes were site-specifically introduced into firefly luciferase. Computational strategies were applied to guide the selection of potential photoswitchable sites that lead to a reversibly controlled luciferase enzyme. In addition, the new azobenzene analogs provide enhanced thermal stability, high photoconversion, and responsiveness to visible light. These small-mol. photoswitches can reversibly photocontrol protein function with excellent spatiotemporal resolution, and preferred sites for incorporation can be computationally determined, thus providing a new tool for investigating biol. processes. The experimental process involved the reaction of (3,5-Difluoro-4-nitrophenyl)methanol(cas: 1123172-89-3SDS of cas: 1123172-89-3)
(3,5-Difluoro-4-nitrophenyl)methanol(cas: 1123172-89-3) belongs to nitro compounds. Nitro compounds have very different half-wave potentials. They depend on the type, number and position of the substituents and rise.SDS of cas: 1123172-89-3
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