Category: alcohols-buliding-blocksOn October 2, 2020 ,《Trans-Selective and Switchable Arene Hydrogenation of Phenol Derivatives》 was published in ACS Catalysis. The article was written by Wollenburg, Marco; Heusler, Arne; Bergander, Klaus; Glorius, Frank. The article contains the following contents:
A trans-selective arene hydrogenation of abundant phenol derivatives catalyzed by a com. available heterogeneous palladium catalyst was reported. The described method tolerates a variety of functional groups and provides access to a broad scope of trans-configurated cyclohexanols as potential building blocks for life sciences and beyond in a one-step procedure. The transformation is strategically important because arene hydrogenation preferentially delivers the opposite cis-isomers. The diastereoselectivity of the phenol hydrogenation can be switched to the cis-isomers by employing rhodium-based catalysts. Moreover, a protocol for the chemoselective hydrogenation of phenols to cyclohexanones was developed. In the experiment, the researchers used trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Category: alcohols-buliding-blocks)
trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Category: alcohols-buliding-blocks It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts