Adding a certain compound to certain chemical reactions, such as: 155310-11-5, 3-Amino-2,2-difluoropropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 155310-11-5, blongs to alcohols-buliding-blocks compound. SDS of cas: 155310-11-5
Into a 40-mL round-bottom flask, was placed 3-amino-2, 2-difluoropropan-l-ol (1 g, 9.002 mmol, 1 equiv), DCM (10 mL), Et3N (1.37 g, 13.539 mmol, 1.50 equiv), TsCl (1.72 g, 9.002 mmol, 1.0 equiv). The resulting solution was stirred for overnight at room temperature. The resulting mixture was concentrated. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (0: 1- 1:2). This resulted in 600 mg (25.13%) of N-(2,2-difluoro- 3-hydroxypropyl)-4-methylbenzene-l-sulfonamide as a white solid. 1H-NMR- 1(300 MHz, CDCl3, ppm) d 7.76- 7.73 (d, J = 9.0 Hz, 2H), 7.35 – 7.32 (d, J = 9.0 Hz, 2H), 5.04- 5.00 (m, 1H), 3.91 – 3.83 (m, 2H), 3.46 – 3.35 (m, 2H), 2.45 (s, 3H).
The synthetic route of 155310-11-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NEWAVE PHARMACEUTICAL INC.; CHEN, Yi; (475 pag.)WO2020/41406; (2020); A1;,
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