Reference of 29194-04-5, Adding some certain compound to certain chemical reactions, such as: 29194-04-5, name is 2-(Benzyl(methyl)amino)-1-phenylethanol,molecular formula is C16H19NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 29194-04-5.
General procedure: A mixture of the substituted benzaldehyde (1.0mmol),finelyground sarcosine (0.13 g, 1.5 mmol),and paraformaldehyde (0.09g, 3.0 mmol)was refluxedin dry benzene (3.3 mL),with magnetic stirring and removal of formed water by means of a Dean-Starktrap, for 6-8h. The resulting solution was evaporated in vacuo to give the oily 5-aryl-3-methyloxazolidine 6. This was dissolved in toluene (1 mL)and quickly added to asolution of ArMgBr prepared from ArBr (1.5 mmol)and Mg (0.04g, 1.5 mmol)in THF (2mL)at 0 C with vigorous stirring. The mixture was left overnight at room temperature. Concentrated HCl (0.25 mL, 3.0 mmol)and toluene (3mL)were added with stirring to the cooled solution ( 5 C). The organic layer was decanted and the precipitate additionally washed with toluene and Et 2O. After basification with an excess of aq NH 3, extraction with CH 2Cl2 (2 2 mL),drying over Na 2SO4, and evaporation, the corresponding N-benzyl-b-hydroxyphenethylamine 7 was obtained. This was dissolved in CH 2Cl2 (2 mL)and treated dropwise with concd H2SO4 (2 mL)(96%-for 7a,b, 75%-for 7d,e) over 5min. After stirring for 2h, ice chips were added and the aq solution made basic with aq NaOH solution. The mixture was extracted with CH 2Cl2 (2 2 mL)and the combined organic extracts dried over anhydrous Na 2SO4, filteredthrough athin layer of silica gel and concentrated in vacuo. Amino alcohols 7c and 7f were cyclized using AlCl 3 in CH 2Cl2 (4.0 equiv, reflux,1.5 h)and polyphosphoric acid (1.1gof PPA- 1 mmol of 7f, 80-90 C, 1.5 h),respectively. The free bases were converted into hydrochloride salts with anhydrous ethereal HCl solution generated in situ from i-PrOH (1.3 equiv)and AcCl (1.1equiv).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 29194-04-5, 2-(Benzyl(methyl)amino)-1-phenylethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Moshkin, Vladimir S.; Sosnovskikh, Vyacheslav Ya.; Tetrahedron Letters; vol. 54; 21; (2013); p. 2699 – 2702;,
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