Application of 558-43-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.558-43-0, name is 2-Methylpropane-1,2-diol, molecular formula is C4H10O2, molecular weight is 90.121, as common compound, the synthetic route is as follows.
General procedure: To a 50 mL flask, the coumarin (1 mmol), appropriate amount of NXS, the Lewisacid catalyst and 20 mL anhydrous solvent were added in. The mixture was heated toreflux with a condenser under the protection of a drying tube. The reaction progresswas monitored by TLC. When the reaction was completed, the mixture was cooled toroom temperature. The solvent was removed by vacuum rotary evaporation, and theresidue was dispensed in 25 mL 5% sodium hydrogen sulfite (NaHSO3) aqueoussolution and then extracted with 25 mL ethyl acetate (EtOAc) for three times. Theorganic layer was combined, washed with 10 mL water and dried over anhydroussodium sulphate (Na2SO4). After the solvent was removed, the crude product waspurified by silica gel (300-400 mesh) column chromatograph.
The chemical industry reduces the impact on the environment during synthesis 558-43-0, I believe this compound will play a more active role in future production and life.
Reference:
Article; Su, Jinling; Zhang, Yan; Chen, Mingren; Li, Weiming; Qin, Xuewei; Xie, Yanping; Qin, Lixiao; Huang, Shihua; Zhang, Min; Synlett; vol. 30; 5; (2019); p. 630 – 634;,
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