In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 155310-11-5, name is 3-Amino-2,2-difluoropropan-1-ol, the common compound, a new synthetic route is introduced below. Quality Control of 3-Amino-2,2-difluoropropan-1-ol
EXAMPLE 28; Preparation of Compound 79; Step 1 & Step 2; Into the solution of 2,2-difluoro-3-aminopropionic acid (2 g, 14.4 mmol) in 40 mL of THF, was added 2N LAH solution in THF at 0 C. The mixture was heated to reflux for 3 h. After cooling to 0 C., 1.75 mL of 5N KOH water solution was added and the mixture was filtered. The solid was washed with 40 ml of THF. The combined filtrates were dried with MgSO4. After removal of the solvent in vacuo, 525 mg of the desired compound 73 was obtained.To the crude compound 73 in 100 mL of toluene, was added TEA (552 mg, 5.46 mmol) and phthalic anhydrite (740 mg, 5 mmol). After azeotroping for 3 h, the toluene was removed in vacuo and the residue was purified by preparative flash chromatography (silica gel, ethyl acetate/hexane, 1:4) to afford the desired product 74 (358 mg): 1H NMR (CDCl3); 7.92 (2H, m), 7.8 (2H, m), 4.21(2H, t), 3.74 (2H, m) 3.23(1H, br; OH) MS [M+H]=241.89
The synthetic route of 155310-11-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Gilead Sciences, Inc.; US2010/22508; (2010); A1;,
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