With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.54410-90-1, name is 4-Pentylcyclohexanol, molecular formula is C11H22O, molecular weight is 170.2918, as common compound, the synthetic route is as follows.SDS of cas: 54410-90-1
EXAMPLE 11 Preparation of 6-ethyl-trans-decalin-2-carboxylic acid trans-4-pentyl-1-cyclohexyl ester 2.10 g of 6-ethyl-trans-decalin-2-carboxylic acid, prepared according to Example 5, are dissolved in 30 ml of absolute methylene chloride and treated with a solution 1.87 g of 4-pentyl-trans-cyclohexanol in 20 ml of absolute methylene chloride. Subsequently, there are added 0.20 g of 4-(dimethylamino)pyridine and, after cooling to 5 C., while stirring 2.48 g of solid dicyclohexylcarbodiimide. Dicyclohexylurea begins to separate out after a short time. After 1 hour at 2 C. and 1.25 hours at room temperature, the precipitate is removed by filtration under suction and back-washed with methylene chloride and hexane. By evaporating the filtrate in vacuo, there are obtained 4.80 g of crude 6-ethyl-trans-decalin-2-carboxylic acid trans-4-pentyl-1-cyclohexyl ester which, for purification, is chromatographed on 90 g of silica gel. Elution with hexane/toluene (1:1) yields 3.22 g of substance which is recrystallized from hexane up to constant melting point and clearing point and dried up to constant weight in a high vacuum (0.01 mbar). There is obtained 6-ethyl-trans-decalin-2-carboxylic acid trans-4-pentyl-1-cyclohexyl ester as colorless crystals; m.p. 50.4 C., cl.p. 86.3 C. The following compound can be prepared in an analogous manner: 6-Butyl-trans-decalin-2-carboxylic acid trans-4-pentyl-1-cyclohexyl ester; m.p. 62.2-65.4 C.; cl.p. 109.3 C.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,54410-90-1, 4-Pentylcyclohexanol, and friends who are interested can also refer to it.
Reference:
Patent; Hoffmann-La Roche Inc.; US4391731; (1983); A;,
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