Adding a certain compound to certain chemical reactions, such as: 1202577-61-4, trans-(4-(Trifluoromethyl)cyclohexyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1202577-61-4, blongs to alcohols-buliding-blocks compound. Computed Properties of C8H13F3O
To a solution of 489 trans-4-(trifluoromethyl)cyclohexyl)methanol (209 mg, 1.15 mmol) in 12 DMF (4 mL) was added 490 sodium bis(trimethylsilyl)amide (1.15 mL, 1.0 M, 1.15 mmol) at rt and after stirring at rt for 5 min., 154 6-bromo-3-isopropyl-7-methylimidazo[1,5-a]pyrazin-8(7H)-one (238 mg, 0.88 mmol) was added as a solid. After stirring at rt for 2 h, the mixture was diluted with a 1 M solution of 195 NH4Cl, 18 water and 68 DCM, partitioned and the aqueous layer was extracted with DCM (2×15 mL). The combined organic extracts were dried (MgSO4) and evaporated. The residue was purified (FCC, SiO2, 10-100% EtOAc/heptanes) to provide the 491 title compound (131 mg, 40%) as a white solid. 1H NMR (400 MHz, CDCl3) delta 7.86 (s, 1H), 6.34 (s, 1H), 3.81 (d, J=6.0 Hz, 2H), 3.42 (s, 3H), 3.14 (td, J=6.8, 13.7 Hz, 1H), 2.14-2.02 (m, 5H), 1.92 (dtt, J=3.2, 6.0, 12.0 Hz, 1H), 1.47-1.40 (m, 8H), 1.28-1.12 (m, 2H). [M+H]=372.3.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1202577-61-4, its application will become more common.
Reference:
Patent; Dart NeuroScience, LLC; Bookser, Brett; Botrous, Iriny; Branstetter, Bryan; Dyck, Brian; Weinhouse, Michael; US2019/177327; (2019); A1;,
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