Synthetic Route of 1124-63-6, Adding some certain compound to certain chemical reactions, such as: 1124-63-6, name is 3-Cyclohexylpropan-1-ol,molecular formula is C9H18O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1124-63-6.
The crude mixture was reacted with phthalimide (15.0 mmol) in THF (20 mL) under reflux for 2 h to get a the phthalimide intermediate as white powder. It was filtered and further reacted with hydrazine (98%, 63 mmol) in absolute ethanol (15 mL) at 60 C for 30 min. The reaction mixture was diluted with water and extracted using ethyl acetate to get the 3-cyclohexylpropan-1-amine 47. The amine 47 was reacted with phenethylisocyanate according to the general procedure to get 23. Yield 87%; White solid; mp 84-86 C; Rf 0.40 (1: 2 Ethylacetate: Hexane), IR (neat): 3359, 3307, 2911, 2849, 1625, 1560, 1496 cm-1; 1H NMR (CDCl3) delta 0.81-0.89 (m, 2H), 1.11-1.26 (m, 6H), 1.41-1.49 (m, 2H), 1.62-1.69 (m, 5H), 2.81 (t, J = 8.00 Hz, 2H), 3.05-3.10 (m, 2H), 3.41-3.46 (m, 2H), 4.26-4.33 (m, 2H), 7.19-7.24 (m, 3H), 7.28-7.33 (m, 2H). 13C NMR (CDCl3) delta 26.24, 26.53, 27.45, 33.24, 34.51, 36.37, 37.33, 40.82, 41.57, 126.40, 128.59, 128.86, 139.30, 158.31. HRMS Calcd for C18H28N2O2 m/z [M+H] 289.2281, found 289.2308.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1124-63-6, 3-Cyclohexylpropan-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Manickam, Manoj; Jalani, Hitesh B.; Pillaiyar, Thanigaimalai; Sharma, Niti; Boggu, Pulla Reddy; Venkateswararao, Eeda; Lee, You-Jung; Jeon, Eun-Seok; Jung, Sang-Hun; European Journal of Medicinal Chemistry; vol. 134; (2017); p. 379 – 391;,
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