Application of 4720-29-0 , The common heterocyclic compound, 4720-29-0, name is 3-(Benzylamino)-1-propanol, molecular formula is C10H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
1,1-bis(methylthio)-2-nitroethylene 9 (1.00 g, 6.06 mmol) was added to asolution of N-benzylamino-3-propan-1-ol 8a (1.00 g, 6.06 mmol) and DMAP (0.74 g, 6.06mmol) in t-butanol (20 mL). The resulting solution was heated to reflux for 24 h under nitrogenatmosphere. The reaction was monitored by TLC (CH2Cl2/MeOH, 97/3). After cooling to roomtemperature, the solvent was removed in vacuo to afford an oily residue which was purified byflash chromatography on silica gel (CH2Cl2/MeOH, 98/2) to give nitroacetamide 11a (oil, 0.42 g,28%), a mixture of (Z)- and (E)-isomers in a ratio close to 1/1.
The synthetic route of 4720-29-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Fante, Bamba; Soro, Yaya; Siaka, Sorho; Marrot, Jerome; Coustard, Jean-Marie; Synlett; vol. 25; 7; (2014); p. 969 – 974;,
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