The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 68327-04-8, name is (1S,2S)-2-Aminocyclopentanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 68327-04-8
H) 6- (2-fluoro-4- ( lH-pyrazol-l-yl ) benzyl ) -2- ( (1S,2S) -2- hydroxycyclopentyl ) -4 , 5-dimethylisoindolin-l-on.e A solution of methyl 5- (2-fluoro-4- ( lH-pyrazol-1- yl) benzyl) -2-formyl-3, 4-dimethylbenzoate (0.17 g) , (lS,2S)-2- aminocyclopentanol hydrochloride (0,06 g) , triethylamine (0.06 mL) and anhydrous magnesium sulfate (0.10 g) in THF (3.40 mL) was stirred at room temperature for 10 hr. The insoluble substance was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was diluted with methanol (3.40 mL) and THF (3.40 mL) , sodium triacetoxyborohydride (0.19 g) was added thereto, and the mixture was stirred overnight at room temperature. The reaction mixture was diluted with ethyl acetate, and the mixture was washed with water and saturated brine. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (0.07 g) . XH NMR (300 MHz, DMSO-d6) delta 1.45-1.60 (1H, m) , 1.62-1.79 (3H, m) , 1.80-1.98 (2H, m) , 2.24 (3H, ‘s), 2.25 (3H, s), 4.08-4.29 (4H, m),.4.39 (2H, s) , 4.88 (1H, d, J = 4.9 Hz), 6.52-6.58 (1H, m) , 7.15 (1H, t, J = 8.4 Hz), 7.23 (1H, s) , 7.63 (1H, dd, J = 8.3, 2.1 Hz), 7.68-7.77 (2H, m) , 8.52 (1H, d, J = 2.5 Hz).
With the rapid development of chemical substances, we look forward to future research findings about 68327-04-8.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; YAMADA, Masami; SUZUKI, Shinkichi; SUGIMOTO, Takahiro; NAKAMURA, Minoru; SAKAMOTO, Hiroki; KAMATA, Makoto; WO2015/163485; (2015); A1;,
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