Synthetic Route of 148043-73-6 , The common heterocyclic compound, 148043-73-6, name is 4,4,5,5,5-Pentafluoropentan-1-ol, molecular formula is C5H7F5O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step-6.1: Synthesis of 4,4,5,5,5-pentafluoropentyl methanesulfonate To a stirred solution of 4,4,5,5,5-pentafluoropentan-l-ol (7.5 g, 42.13 mmol) in dichloromethane (100 mL) at 0 C was added triethylamine (7.1 mL, 50.56 mmol) and methane sulfonyl chloride (3.53 mL, 46.34 mmol). The reaction mixture was stirred for 1 h at RT and diluted with dichloromethane. The organic layer was washed with water, brine, dried over anhydrous Na2S04 and concentrated under reduced pressure to afford 4,4,5,5,5- pentafluoropentyl methanesulfonate (6.0 g, 56%) as a brown colour liquid.
The synthetic route of 148043-73-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; HAO, Ming-Hong; KORPAL, Manav; NYAVANANDI, Vijay Kumar; PUYANG, Xiaoling; SAMAJDAR, Susanta; SMITH, Peter Gerard; WANG, John; ZHENG, Guo Zhu; ZHU, Ping; (161 pag.)WO2016/196342; (2016); A1;,
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